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Journal of the American College of Nutrition, Vol 14, Issue 6 565-578, Copyright © 1995 by American College of Nutrition

JOURNAL ARTICLE

Ascorbic acid and gastrointestinal cancer

M. Cohen and H. N. Bhagavan
Scientific Information Services, Hoffmann-La Roche, Nutley, NJ 07110, USA.

A literature review was made to critically evaluate the ability of ascorbic acid to modulate the incidence of gastrointestinal cancer. A comparison of preclinical, clinical, and epidemiological studies indicated that evidence for ascorbic acid as an inhibitor of carcinogenesis is stronger with regard to gastric cancer and weaker with regard to esophageal and colon/rectal cancer. Insufficient evidence currently exists regarding the oral cavity and the use of ascorbic acid in precancerous conditions such as polyposis and leukoplakia.


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