HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Verma, S. Articles by McNeill, J. H. Search for Related Content PubMed PubMed Citation Articles by Verma, S. Articles by McNeill, J. H.

Nutritional Factors that Can Favorably Influence the Glucose/Insulin System: Vanadium

Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC Canada

Address reprint requests to: John H. McNeill, PhD, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, B.C. V6T 1Z3 Canada

A growing body of experimental and clinical research indicates that the trace element, vanadium, exerts potent insulin-mimetic effects in vitro and in vivo when used in pharmacological doses. Since our first demonstration of the anti-diabetic and cardioprotective effects of vanadium in vivo, impressive advances have been made in our understanding of its mechanism of action, pharmacokinetics and pharmacodynamics. A major advance in the use of vanadium as an insulin-mimetic has been the development of organic vanadium complexes which are 2 to 3 times as potent as inorganic vanadium and have been extensively studied in our laboratory. There is an emerging role for the use of vanadium in human diabetes and the recently conducted clinical trials support this contention. The present review summarizes some of the key aspects of vanadium biology which exemplify the potent insulin-mimetic, anti-diabetic and antihypertensive effects of this intriguing trace element.

Key words: Vanadium, diabetes, insulin resistance

This article has been cited by other articles:

				D.M. Smith, R.M. Pickering, and G.T. Lewith A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus QJM, May 1, 2008; 101(5): 351 - 358. [Abstract] [Full Text] [PDF]

				D. V Aminot-Gilchrist and H. D. Anderson Insulin resistance--associated cardiovascular disease: potential benefits of conjugated linoleic acid Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1159S - 1163S. [Abstract] [Full Text] [PDF]

				E C Opara Oxidative stress, micronutrients, diabetes mellitus and its complications The Journal of the Royal Society for the Promotion of Health, March 1, 2002; 122(1): 28 - 34. [Abstract] [PDF]

				M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al. Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications Diabetes Care, January 1, 2002; 25(1): 148 - 198. [Full Text] [PDF]

				K. Cusi, S. Cukier, R. A. DeFronzo, M. Torres, F. M. Puchulu, and J. C. P. Redondo Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1410 - 1417. [Abstract] [Full Text]