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Journal of the American College of Nutrition, Vol. 17, No. 4, 337-341 (1998)
Published by the American College of Nutrition

Plasma Antioxidants and Lipid Peroxidation in Acute Myocardial Infarction and Thrombolysis

Yishai Levy, MD, Peter Bartha, MD, Ami Ben-Amotz, PhD, J. Gerald Brook, MD, Gertrude Dankner, Shai Lin, MD, PhD and Haim Hammerman, MD

Lipid Research Unit (Y.L., P.B., J.G.B., G.D.), Haifa, ISRAEL
National Oceanographic Research Institute (A.B-A.), Haifa, ISRAEL
Department of Clinical Epidemiology (S.L.), Haifa, ISRAEL
Department of Cardiology (H.H.), Rambam Medical Center and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, ISRAEL

Address reprint requests to: Yishai Levy, MD, Dept. Medicine D, Rambam Medical Center, Haifa 31096 ISRAEL

Objectives: The aim of this study was to investigate the balance between prooxidative and protective mechanisms in patients with acute myocardial infarction (AMI) throughout streptokinase (STK) therapy.

Methods: Patients who presented to coronary care unit within 3 hours of infarction were followed. Blood was collected before, 2 and 24 hours post STK. Plasma lipid peroxidation was analyzed by a free radical generating system (AAPH) and malondialdehyde equivalents and conjugated dienes quantitated. Plasma vitamins A, E and ß-carotene, were analyzed by HPLC. Patients’ results were compared with those from age-matched, healthy control subjects.

Results: In 38 patients with AMI, baseline plasma antioxidant vitamin concentration was reduced compared with a healthy control group. Upon STK therapy, there was a significant drop in plasma vitamin E concentration. Successful reperfusion was followed by an increased plasma oxidizability. Plasma lipids were not significantly different in the AMI patients except for a lower HDL-cholesterol concentration.

Conclusions: Patients with AMI showed a drop in plasma antioxidant vitamins. Upon thrombolysis, there was an enhanced lipid peroxidation. These alterations indicate the significance of free radical generation processes in reperfusion injury in AMI patients, and suggest the potential involvement of antioxidants in the management of AMI treated by thrombolysis.

Key words: thrombolysis, lipid peroxidation, antioxidants, acute myocardial infarction






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Copyright © 1998 by the American College of Nutrition.