HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Janghorbani, M. Articles by Daniels, L. Search for Related Content PubMed PubMed Citation Articles by Janghorbani, M. Articles by Daniels, L.

Metabolism of Selenite in Men with Widely Varying Selenium Status

BioChemAnalysis Corp and the Center for Stable Isotope research Inc, 2201 West Campbell Park Drive, Chicago, Illinois (M.J.)
Chinese Academy of Preventive Medicine, Institute of Nutrition and Food Hygiene, Beijing, People’s Republic of CHINA (Y.X., P.H.)
Department of Agricultural Chemistry, Oregon State University, Corvallis, Oregon (P.D.W., J.A.B.)
Microscopic and Chemical Analysis Research Center, Ohio State University, Columbus, Ohio (J.W.O., L.D.)

Address reprint requests to: P.D. Whanger, Ph.D., Department of Agricultural Chemistry, Oregon State University, Corvallis, OR 97331

Objective: This study was undertaken to investigate the metabolism of selenite in men with life-long intakes of deficient, adequate and excess selenium.

Methods: Stable isotopes of selenium were infused for five hours into Chinese men living in deficient, adequate or excessive selenium areas, and 24-hour urine and blood samples were collected daily for the next seven days. Stable isotopic selenium excretion was determined in urine and in whole plasma and plasma fractions.

Results: Even though there was a positive correlation of selenium intake with the urinary excretion of this element, this relationship was not linear over the entire range (deficient, adequate, excessive) of selenium intake. When the urine excretion was normalized internally within each group, a sharp increase in the slope of this relationship was found when long-term intake increased to adequate amounts, but the slope reached a plateau when the daily intake exceeded the adequate group. The plasma selenoprotein P fraction was labeled initially, but the incorporation in the glutathione peroxidase fraction subsequently increased by a small amount. A two-month dietary restriction of selenium of the subjects from the excess area did not result in a reduction of urinary excretion of infused selenite.

Conclusion: A complex relationship exists between long-term intake of selenium and selenium status, and subjects living in the excess area are more saturated with selenium than anticipated. More than two months of depletion are required to affect urinary excretion of selenium.

Key words: stable isotopes of selenium, Chinese men, deficient selenium, adequate selenium, excess selenium, selenoprotein P, plasma, urine

This article has been cited by other articles:

				C. J. Klein, F. H. Nielsen, and P. B. Moser-Veillon Trace Element Loss in Urine and Effluent Following Traumatic Injury JPEN J Parenter Enteral Nutr, March 1, 2008; 32(2): 129 - 139. [Abstract] [Full Text] [PDF]

				W. C. Hawkes, F. Z. Alkan, and L. Oehler Absorption, Distribution and Excretion of Selenium from Beef and Rice in Healthy North American Men J. Nutr., November 1, 2003; 133(11): 3434 - 3442. [Abstract] [Full Text] [PDF]