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Original Research |
Center for Nutrition (M.S.B., L.A.S.) at Meharry Medical College, 1005 D.B. Todd Blvd., 21st Avenue South, Nashville, Tennessee
Comprehensive Sickle Cell Center (E.A.T.) at Meharry Medical College, 1005 D.B. Todd Blvd., 21st Avenue South, Nashville, Tennessee
Department of Medicine (K.Y.C., M.S.B.) at Vanderbilt University Medical Center, 21st Avenue South, Nashville, Tennessee
Department of Surgery (P.J.F.) at Vanderbilt University Medical Center, 21st Avenue South, Nashville, Tennessee
Department of Preventive Medicine (B.G.M.) at Vanderbilt University Medical Center, 21st Avenue South, Nashville, Tennessee
Address reprint requests to: Maciej S. Buchowski, PhD, Associate Professor, Center for Nutrition, Meharry Medical College, 1005 D.B. Todd Blvd., Nashville, TN 37208
Objective: To examine the association between fasting plasma leptin concentrations and the hypercatabolic state observed in sickle cell disease (SCD).
Methods: Plasma leptin concentration and resting energy expenditure (REE) were measured in 37 SCD patients (10 men, 12 boys 14 to 18 years-old, seven women, and eight girls 14 to 18 year-old) and in 37 age, gender and fat mass (FM) matched controls. Body composition was measured hydrostatically, REE by whole room-indirect calorimeter, and plasma leptin using an RIA kit.
Results: Plasma leptin concentration and leptin normalized for body fat (ng/dL*kg FM-1) were significantly lower in SCD patients than in non-SCD controls (4.00±3.23 vs. 9.94±14.69, p=0.021 and 0.406±0.260 vs. 0.643±0.561, p=0.024, respectively). A positive linear association between log plasma leptin and FM was observed in both males and females, adjusting for age and SCD status. The strength of this association was greater in females compared with males (slope=0.699 and 0.382 log ng/mL per 10 kg FM, respectively; p=0.013). SCD patients on average demonstrated a higher REE, adjusting for FFM (p<0.0001). Log plasma leptin and FM were not statistically significant predictors of REE after adjustment for FFM and SCD.
Conclusions: Once corrected for body composition, mean plasma leptin concentration was significantly lower among female SCD patients than among non-SCD matched controls. Although REE was higher in SCD patients, there is no simple association between leptin and REE in SCD.
Key words: leptin, sickle cell disease, resting metabolic rate, body composition
This article has been cited by other articles:
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  J. M. Hibbert, L. L. Hsu, S. J. Bhathena, I. Irune, B. Sarfo, M. S. Creary, B. E. Gee, A. I. Mohamed, I. D. Buchanan, A. Al-Mahmoud, et al. Proinflammatory Cytokines and the Hypermetabolism of Children with Sickle Cell Disease Experimental Biology and Medicine, January 1, 2005; 230(1): 68 - 74. [Abstract] [Full Text] [PDF]
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 M. S Buchowski, K. Y Chen, D. Byrne, and W. C Wang Equation to estimate resting energy expenditure in adolescents with sickle cell anemia Am. J. Clinical Nutrition, December 1, 2002; 76(6): 1335 - 1344. [Abstract] [Full Text] [PDF]
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 M. S. Buchowski, F. A. de la Fuente, P. J. Flakoll, K. Y. Chen, and E. A. Turner Increased bone turnover is associated with protein and energy metabolism in adolescents with sickle cell anemia Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E518 - E527. [Abstract] [Full Text] [PDF]
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