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The Wistar Institute, Philadelphia, Pennsylvania (D.K., S.A.T., S.W.)
Department of Pathology, University of Cincinnati, Cincinnati, Ohio (P.T.)
Department of Chemistry, Chestnut Hill College, Philadelphia, Pennsylvania (S.K.C.)
Address reprint requests to: David Kritchevsky, PhD, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104. kritchevsky{at}wistar.upenn.edu.
Objective: To determine effects of conjugated linoleic acid (CLA) on establishment and progression of experimentally-induced atherosclerosis in rabbits.
Methods: For establishment of atherosclerosis, New Zealand White rabbits were fed a semipurified diet containing 0.1% to 0.2% cholesterol for 90 days. Some groups were fed diet and CLA. For effects on progression of atherosclerosis, rabbits with established atherosclerosis were fed a semipurified diet±CLA for 90 days.
Results: At dietary levels as low as 0.1%, CLA inhibited atherogenesis. At dietary levels of 1%, CLA caused substantial (30%) regression of established atherosclerosis. This is the first example of substantial regression of atherosclerosis being caused by diet alone.
Conclusion: Dietary CLA is an effective inhibitor of atherogenesis and also causes regression of established atherosclerosis.
Key words: atherogenesis, conjugated linoleic acid, regression of atherosclerosis, experimental artherosclerosis, rabbits
Abbreviations: CLA • conjugated linoleic acid • LDL • low density lipoprotein
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