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Postprandial Leptin Response to Carbohydrate and Fat Meals in Obese Women

Service de Nutrition, Faculté de Médecine (M.R.), Institut Pasteur Lille, Lille Cedex, FRANCE
INSERM U 545 (P.L., J.-C.F.), Institut Pasteur Lille, Lille Cedex, FRANCE
INSERM U 508 (J.D.), Institut Pasteur Lille, Lille Cedex, FRANCE

Address reprint requests to: Monique Romon, MD, PhD, Service de Nutrition, Faculté de Médecine, 59045 Lille Cedex, FRANCE. E-mail: mromon{at}univ-lille2.fr

Objective: To assess the postprandial leptin responses to a carbohydrate and a fatty meal in obese subjects and its association with postprandial insulin response.

Methods: Eight obese and 11 lean women were given, in a random order, an isocaloric carbohydrate meal (3.43 MJ, 166g of carbohydrates, 38g of proteins) or fat meal (3.35 MJ, 70g of fat, 36g of proteins) or remained fasting. Blood samples were collected hourly during the nine hours after the meal for leptin, insulin, C-peptide and glucose determinations.

Results: In obese subjects, as in lean subjects, postprandial leptin response, calculated as the increment above fasting values, was higher after the carbohydrate meal than after the fatty meal (p < 0.01). However, after the carbohydrate meal, postprandial leptin increment was lower (p < 0.05) in obese subjects than in lean controls. In contrast, there was no difference in postprandial leptin response between lean and obese subjects after the fatty meal. Correlation analyses showed that the area under the postprandial leptin response curve (leptin AUC) was correlated to insulin AUC in lean (r = 0.70, p < 0.01), but not in obese subjects.

Conclusion: These results indicate that postprandial leptin response is lower after a carbohydrate meal in obese women than in lean controls, suggesting an impairment of postprandial leptin regulation in obese women.

Key words: leptin, insulin, obesity, carbohydrate

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