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Journal of the American College of Nutrition, Vol. 23, No. 5, 506S-509S (2004)
Published by the American College of Nutrition

Clinical Efficacy of Magnesium Supplementation in Patients with Type 2 Diabetes

Kuninobu Yokota, MD, Mitsutoshi Kato, MD, Frank Lister, PhD, Hirokazu Ii, DC, Toshiyuki Hayakawa, PhD, Tetsuya Kikuta, DC, Shigeru Kageyama, MD and Naoko Tajima, MD

Department of Internal Medicine (K.Y., N.T.), Tokyo, JAPAN
Kato Medical Clinic (M.K.), Tokyo, JAPAN
Department of Anatomy (T.H.), Tokyo, JAPAN
Department of Clinical Pharmacology & Therapeutics (S.K.), Tokyo, JAPAN
Jikei University School of Medicine, Matier Co. Ltd. (H.I., T.K.), Tokyo, JAPAN
WA Salt Supply, AUSTRALIA (F.L.)

Address reprint requests to: Dr. Kuninobu Yokota, 3-15-8 Nishi-shinbashi Minato-ku 105-0003, JAPAN. E-Mail: yokota{at}jikei.ac.jp

Effects of magnesium (Mg) supplementation on nine mild type 2 diabetic patients with stable glycemic control were investigated. Water from a salt lake with a high natural Mg content (7.1%) (MAG21) was used for supplementation after dilution with distilled water to 100mg/100mL; 300mL/day was given for 30 days. Fasting serum immunoreactive insulin level decreased significantly, as did HOMA{square}R (both p < 0.05). There was also a marked decrease of the mean triglyceride level after supplementation. The patients with hypertension showed significant reduction of systolic (p < 0.01), diastolic (p = 0.0038), and mean (p < 0.01) blood pressure. The salt lake water supplement, MAG21, exerted clinical benefit as a Mg supplement in patients with mild type 2 diabetes mellitus.

Key words: magnesium supplementation, type 2 diabetes mellitus, hypertension, insulin-resistance, hypertriglyceridemia, life style-related diseases




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