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Journal of the American College of Nutrition, Vol. 23, No. 6, 732S-737S (2004)
Published by the American College of Nutrition

Development of Cellular Magnesium Nano-Analysis in Treatment of Clinical Magnesium Deficiency

Burton B. Silver, PhD

University of Louisville, School of Medicine, Department of Physiology & Biophysics, Louisville, Kentucky (Ret), and IntraCellular Diagnostics, Inc., Foster City, California

Address reprint requests to: Burton B. Silver, Ph.D., IntraCellular Diagnostics, Inc. 553 Pilgrim Dr (B), Foster City, CA. E-mail: DocBurt{at}aol.com

A novel technique, using energy dispersive X-ray microanalysis (EXA tm), for noninvasive intracellular (i.c.) measurement of magnesium [Mg 2+] i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Since only 1% of total body Mg 2+ is found in the intravascular space, serum levels of Mg 2+ give little information about a patient’s overall Mg 2+ status with respect to this essential mineral. Using the EXA tm analysis it has shown been determined that Mg 2+ levels are significantly reduced in many physiological states which may lead to serious pathological conditions [15]. Description of the methodology and examples of data as well as potential applications will focus on intracellular (i.c.) [Mg 2+] i determinations obtained in cells from subjects with cardiovascular disease (CVD) syndromes related to Mg 2+ deficiency. Examples of the application of EXA tm evaluation include examination of intracellular magnesium and other minerals in a wide spectrum of conditions which include cardiovascular conditions, arrhythmias, heart failure, myocardial infarction, and bypass surgery. Standardization of control values were performed at NASA [12].

Key words: x-ray microanalysis, nano-analysis, cellular magnesium, non-invasive measurement






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