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Journal of the American College of Nutrition, Vol. 24, No. 1, 10-15 (2005)
Published by the American College of Nutrition

Magnesium and Intrauterine Growth Restriction

Naila O.E. Barbosa, MD, Thelma S. Okay, MD, PhD and Cléa R. Leone

Department of Pediatrics (N.O.E.B., C.R.L.), School of Medicine, Laboratory of the Children’s Hospital "Prof. Pedro de Alcântara", Hospital das Clínicas (T.S.O.), University of São Paulo, São Paulo, BRAZIL

Address reprint requests to: Naila de Oliveira Elias Barbosa, M.D., Alameda Fernão Cardim n° 99 apartamento 11, Jardim Paulista, São Paulo—SP, CEP: 01403-020, BRAZIL. E-mail: naila{at}ajato.com.br

Background: The presence of intrauterine growth restriction (IUGR), could potentially lead to imbalances of Mg homeostasis, which have not yet been fully clarified.

Objective: To describe, in term newborn (NB) without IUGR, ionized magnesium (iMg) and total magnesium (TMg) concentrations in umbilical cord blood, on the third and seventh days of life and to compare these values with those of term NB with IUGR.

Methods: A prospective study was performed on 70 term NB divided into two groups: Group I—30 NB without IUGR and Group II—40 NB with IUGR. TMg concentrations were determined in sera by a classical colorimetric end point method (Cobas-Mira, Roche), and iMg was determined in whole blood by means of the Stat Profile-M analyzer (NOVA Biomedical).

Results: We found that in term NB without IUGR, TMg concentrations increased during the first week of life and were lower than those of NB with IUGR in cord blood (p < 0.05). NB without IUGR had decreased iMg concentrations in comparison to NB with IUGR in all sampling times, i.e., cord blood, third and seventh days of life (p < 0.001). iMg concentrations remained unchanged during the study period. We also found that all NB enrolled in the study presented with low iMg concentrations (reference interval 0.4–0.6 mmol/L).

Conclusion: The presence of IUGR may influence neonatal levels of magnesium, suggesting an effect on the modulation of this ion homeostasis, during the perinatal period.

Key words: intrauterine growth restriction, term newborn, magnesium, ionized magnesium, total magnesium

Abbreviations: iMg = Ionized magnesium • IUGR = intrauterine growth restriction • Mg = Magnesium • NB = newborn • TMg = total magnesium




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[Abstract] [Full Text] [PDF]


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