| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Family Medicine (D.E.K., A.G.M., M.E.G.), Medical University of South Carolina, Charleston, South Carolina
Department of Biometry, Bioinfomatics, and Epidemiology (R.F.W.), Medical University of South Carolina, Charleston, South Carolina
Address correspondence to: Dana E. King, MD, Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, PO Box 250192, Charleston, SC 29425. E-mail: kingde{at}musc.edu
Objective: Current dietary guidelines recommend adequate intake of magnesium (310–420mg daily) in order to maintain health and lower the risk of cardiovascular disease. Recent evidence from animal and clinical studies suggests that magnesium may be associated with inflammatory processes. The objective of this study was to determine whether dietary magnesium consumption is associated with C-reactive protein (CRP), a marker of inflammation, in a nationally representative sample.
Methods: Analysis of adult (
17 years) participants in a cross-sectional nationally representative survey (National Health and Nutrition Examination Survey 1999–2000 [NHANES]) who were not taking magnesium or magnesium-containing supplements. The primary outcome measure was high sensitivity CRP (elevated 3.0mg/L).
Results: Among US adults, 68% consumed less than the recommended daily allowance (RDA) of magnesium, and 19% consumed less than 50% of the RDA. After controlling for demographic and cardiovascular risk factors, adults who consumed <RDA of magnesium were 1.48–1.75 times more likely to have elevated CRP than adults who consumed RDA (Odds Ratio [OR] for intake <50% RDA = 1.75, 95% Confidence Interval [CI] 1.08–2.87). Adults who were over age 40 with a BMI >25 and who consumed <50% RDA for magnesium were 2.24 times more likely to have elevated CRP (95% CI 1.13–4.46) than adults RDA.
Conclusions: Most Americans consume magnesium at levels below the RDA. Individuals with intakes below the RDA are more likely to have elevated CRP, which may contribute to cardiovascular disease risk.
Key words: dietary magnesium, CRP, cardiovascular, inflammation
Abbreviations: AHA = American Heart Association • BMI = body mass index • CDC = Centers for Disease Control and Prevention • CRP = C reactive protein • IOM = Institute of Medicine • NCHS = National Center for Health Statistics • NHANES = National Health and Nutrition Examination Survey • RDA = recommended daily allowance • SUDAAN = This is not an abbreviation, it is the name of statistical software
This article has been cited by other articles:
|
|
 |
|
  M Rodriguez-Moran and F Guerrero-Romero Serum magnesium and C-reactive protein levels Arch. Dis. Child., August 1, 2008; 93(8): 676 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mahabir, Q. Wei, S. L. Barrera, Y. Q. Dong, C. J. Etzel, M. R. Spitz, and M. R. Forman Dietary magnesium and DNA repair capacity as risk factors for lung cancer Carcinogenesis, May 1, 2008; 29(5): 949 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L Pierce, M. A Austin, P. K Crane, B. M Retzlaff, B. Fish, C. M Hutter, D. L Leonetti, and W. Y Fujimoto Measuring dietary acculturation in Japanese Americans with the use of confirmatory factor analysis of food-frequency data Am. J. Clinical Nutrition, August 1, 2007; 86(2): 496 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Song, T. Y Li, R. M van Dam, J. E Manson, and F. B Hu Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1068 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bo, M. Durazzo, S. Guidi, M. Carello, C. Sacerdote, B. Silli, R. Rosato, M. Cassader, L. Gentile, and G. Pagano Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 1062 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J Dominguez, M. Barbagallo, F. Lauretani, S. Bandinelli, A. Bos, A. M. Corsi, E. M Simonsick, and L. Ferrucci Magnesium and muscle performance in older persons: the InCHIANTI study. Am. J. Clinical Nutrition, August 1, 2006; 84(2): 419 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Basu, S. Devaraj, and I. Jialal Dietary Factors That Promote or Retard Inflammation Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 995 - 1001. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
