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Journal of the American College of Nutrition, Vol. 24, No. 5, 334-341 (2005)
Published by the American College of Nutrition

Factors Influencing Zinc Status of Apparently Healthy Indians

Vaishali V. Agte, PhD, Shashi A. Chiplonkar, PhD and Kirtan V. Tarwadi, MSc

Agharkar Research Institute, Pune, INDIA

Address reprint requests to: Vaishali V Agte, PhD, Agharkar Research Institute, G.G. Agarkar Road, Pune 411 004, INDIA. E-mail: vaishaliagte{at}hotmail.com

Objectives: To identify dietary, environmental and socio-economic factors associated with mild zinc deficiency, three zinc status indices; erythrocyte membrane zinc (RBCMZn), plasma zinc and super oxide dismutase (SOD) were assessed in free living and apparently healthy Indian population.

Methods: Dietary patterns of 232 men and 223 women (20–65 yr) from rural, industrial and urban regions of Western India were evaluated by food frequency questionnaire. RBCMZn was estimated using atomic absorption spectrometry, hemoglobin and serum ceruloplasmin by spectrophotometer. On a sub sample (48 men and 51 women) plasma zinc and SOD were also assessed.

Results: Mean RBCMZn was 0.5 ± 0.1 µmols/g protein with 46% individuals showing zinc deficiency. Mean plasma zinc was 0.98 ± 0.12 µg/mL with 25% men and 2.5% women having values below normal range. Mean SOD was 0.97 ± 0.1 (u/mL cells). A significant positive correlation was observed between intakes of green leafy vegetables, other vegetables and milk products with RBCMZn status (p < 0.05). But these were not correlated with plasma zinc (p > 0.2). Cereal and legume intakes were negatively correlated with RBCMZn (p < 0.05) but positively correlated with plasma zinc (p < 0.05) and not correlated with SOD (p > 0.2). Fruit and other vegetable intake were positively correlated with SOD (p < 0.05) alone. Logistic regression analyses revealed that RBCMZn was positively associated with intakes of ß-carotene, zinc and environmental conditions and negatively associated with family size (p < 0.05). Plasma zinc indicated positive association with zinc, thiamin and riboflavin intakes (p < 0.05) and SOD showed negative association with iron and family size.

Conclusion: RBCMZn was a more sensitive indicator of long-term zinc status than plasma zinc and SOD. Prominent determinants of zinc status were intakes of beta-carotene and zinc along with environmental conditions and family size.

Key words: erythrocyte membrane zinc, vegetarian diets, plasma zinc, super oxide dismutase, socio-environmental factors






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