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Journal of the American College of Nutrition, Vol. 25, No. 3, 170-177 (2006)
Published by the American College of Nutrition

Effect of a Nutritional Supplementation on Bone Health in Chilean Elderly Subjects with Femoral Osteoporosis

Daniel Bunout, MD, Gladys Barrera, RN, Laura Leiva, Vivien Gattas, RD, María Pía de la Maza, MD, MSc, Ferdinand Haschke, MD, Philippe Steenhout, MD, Petra Klassen, PhD, Corinne Hager, PhD, Elizabeth Offord, MD and Sandra Hirsch, MD, MSc

INTA (D.B., G.B., L.L., V.G., M.P.d.l.M., S.H.)
Department of Medicine, Central Campus Faculty of Medicine (D.B.)
University of Chile, Santiago, CHILE, Nestec Ltd, Vevey, SWITZERLAND (F.H., P.S., P.K., C.H., E.O.)

Address correspondence to: Daniel Bunout MD, INTA University of Chile, PO Box 138-11, Santiago, CHILE. E-mail: dbunout{at}inta.cl

Objective: To study the effects of a special nutritional supplement on bone mineral density and bone turnover markers in Chilean elderly subjects with femoral osteoporosis.

Setting: Public primary health care clinics in Chile.

Subjects: Free living elderly subjects with femoral osteoporosis.

Interventions: Subjects were randomized to receive the usual nutritional supplement provided by the Chilean Ministry of Health or a special nutritional supplement providing, among other nutrients, 90 mg isoflavones, 800 mg calcium, 400 IU vitamin D, 60 ug vitamin K and 31 g proteins per day.

Measures of Outcome: At baseline, and after six and twelve months of supplementation, body composition, bone mineral density, serum 25 OH vitamin D, intact parathyroid hormone (iPTH), osteocalcin, decarboxylated osteocalcin, urinary aminoterminal telopeptide of type I collagen (NTX), deoxypyridoline cross links (Dpd) and equol were measured. Every month, urinary daidzein was measured in a morning urine sample.

Results: No differences between treatment groups were observed in body composition or bone mineral density changes. The group receiving the special supplement had a significant increase in serum 25 OH vitamin D and a significant decrease in serum iPTH and decarboxylated osteocalcin. No association between daidzein or equol excretion and changes in bone mineralization was observed.

Conclusions: A special supplement delivered to elderly subjects with osteoporosis improved serum vitamin D and reduced serum iPTH and undercarboxylated osteocalcin levels but did not affect BMD.

Key words: soy isoflavones, osteoporosis, bone turnover markers, elderly






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