JACN Did you know that you can get alerts when a new issue is online?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Ishihara, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ishihara, J.
Journal of the American College of Nutrition, Vol. 27, No. 1, 127-136 (2008)
Published by the American College of Nutrition

Intake of Folate, Vitamin B6 and Vitamin B12 and the Risk of CHD: The Japan Public Health Center-Based Prospective Study Cohort I

Junko Ishihara, PhD, Hiroyasu Iso, MD, Manami Inoue, MD, Motoki Iwasaki, MD, Katsutoshi Okada, MD, Yoshikuni Kita, PhD, Yoshihiro Kokubo, MD, Akira Okayama, MD, Shoichiro Tsugane, MD for the JPHC Study Group

Department of Public Health Medicine, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki (J.I., H.I.)
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo (J.I., M.I., M.I., S.T.)
Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka (H.I.)
Department of Public Health, University of Ehime, Ehime (K.O.)
Department of Health Science, Shiga University of Medical Science, Shiga (Y.K.)
Department of Preventive Cardiology, National Cardiovascular Center, Osaka (Y.K., A.O.), JAPAN

Address correspondence to: Prof. Hiroyasu Iso, Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita-shi, Osaka 565-0871, JAPAN. E-mail: iso{at}pbhel.med.osaka-u.ac.jp

Address reprint requests to: Shoichiro Tsugane, MD, Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JAPAN. E-mail: stsugane{at}ncc.go.jp

Objective: To investigate the association of dietary folate, vitamin B6 (VB6) and vitamin B12 (VB12) with the risk of coronary heart disease among middle-aged persons.

Methods: A total of 40,803 subjects aged 40–59 years living in the community who were free of prior diagnoses of cardiovascular disease and cancer and who completed a food frequency questionnaire were followed from 1990–1992 to the end of 2001 in the Japan Public Health Center-based Prospective Study.

Results: After 468,472 person-years of follow-up, 251 coronary heart disease incidents were documented. Coronary heart disease and definite myocardial infarction were inversely associated with dietary intake of folate, VB6 and VB12 after adjustment for age and sex, but the associations were attenuated after further adjustment for smoking, dietary and other cardiovascular risk factors. However, among non-multivitamin supplement users, multivariable hazard ratios (95% confidence intervals) in the highest vs. lowest quintiles of VB6 intake were 0.60 (0.37–0.97) for total coronary heart disease and 0.52 (0.29–0.91) for definite myocardial infarction, and the inverse associations with VB12 were marginally significant. The combination of below-median intake of three vitamins or of only B6 conferred a twice excess risk of total coronary heart disease.

Conclusions: Dietary intake of VB6 was associated with a reduced risk of coronary heart disease among middle-aged non-multivitamin supplement users. Dietary folate and VB12 were also suggested to be protective factors for coronary heart disease.

Key words: folate, vitamin B6, vitamin B12, coronary disease, diet

Abbreviations: CHD=coronary heart disease • CI=confidence interval • FFQ=food frequency questionnaire • HR=hazard ratio • VB6=vitamin B6 • VB12=vitamin B12






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American College of Nutrition.