JACN Did you know that you can get alerts when a new issue is online?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tinahones, F. J.
Right arrow Articles by Cardona, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tinahones, F. J.
Right arrow Articles by Cardona, F.
Journal of the American College of Nutrition, Vol. 27, No. 2, 209-213 (2008)
Published by the American College of Nutrition

Green Tea Reduces LDL Oxidability and Improves Vascular Function

F. J. Tinahones, MD, PhD, M. A. Rubio, MD, PhD, L. Garrido-Sánchez, PhD, C. Ruiz, BSc, E. Gordillo, BSc, L. Cabrerizo, MD, PhD and F. Cardona, BSc, PhD

Servicio de Endocrinología, Hospital Clinico Virgen de la Victoria de Málaga (F.J.T.)
Fundación IMABIS (Instituto Mediterráneo para el Avance de la Biotecnología y la Investigación Sanitaria) de Málaga (L.G.-S., F.C.)
Málaga, Servicio de Endocrinología y Nutrición, Hospital Clínico San Carlos de Madrid (M.A.R., C.R., E.G., L.C.)
Ciber Fisio Patologia de la Obesidad y Nutricion, CB06/03, ISCIII (F.J.T., L.G.-S., F.C.), Madrid, SPAIN

Address reprint requests to: Francisco José Tinahones, c/ Manuel Vazquez Montalban n° 1, Rincón de la Victoria. Málaga, 29720, SPAIN. E-mail: fjtinahones{at}terra.es

Objective: Several different epidemiological studies have examined the association between the consumption of tea and coronary heart disease. Some, though not all, support the view that tea or flavonoids reduce the risk of cardiovascular heart disease. The aim of this study was to determine the short-to medium-term effect of a green tea extract on vascular function and lipid peroxidation as compared with placebo.

Methods: The study was undertaken with 14 healthy women, none of whom were receiving any medical treatment. Measurements were made of antibodies and immune complexes by ELISA, endothelial dependent vascular function by Doppler ultrasound, and the concentration of oxidized LDL by TBARS.

Results: The mean diameter of the brachial artery following the post-compression hyperaemia phase rose significantly (p < 0.0001) after treatment with green tea extract. Flow-mediated brachial artery vasodilation ranged from 5.68% for the placebo phase to 11.98% after the green tea extract (p = 0.02). The consumption of green tea extract was associated with a significant 37.4% reduction in the concentration of oxidized LDL (TBARS) (p = 0.017). The levels of anti-oxidized LDL IgM antibodies fell significantly after treatment (p = 0.002).

Conclusion: This study found that consumption of green tea extract by women for five weeks produced modifications in vascular function and an important decrease in serum oxidizability.

Key words: LDL, oxidized LDL, anti-oxidized LDL IgG antibodies, anti-oxidized LDL IgM antibodies, green tea




This article has been cited by other articles:


Home page
 J. Nutr.Home page
J. Frank, T. W. George, J. K. Lodge, A. M. Rodriguez-Mateos, J. P. E. Spencer, A. M. Minihane, and G. Rimbach
Daily Consumption of an Aqueous Green Tea Extract Supplement Does Not Impair Liver Function or Alter Cardiovascular Disease Risk Biomarkers in Healthy Men
J. Nutr., January 1, 2009; 139(1): 58 - 62.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American College of Nutrition.