JACN Did you know that you can get alerts when a new issue is online?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Forsythe, W. A.
Right arrow Articles by Anderson, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Forsythe, W. A.
Right arrow Articles by Anderson, J. J.

Journal of the American College of Nutrition, Vol 5, Issue 6 533-549, Copyright © 1986 by American College of Nutrition

JOURNAL ARTICLE

Dietary protein effects on cholesterol and lipoprotein concentrations: a review

W. A. Forsythe, M. S. Green and J. J. Anderson

Different dietary proteins exert different effects on plasma cholesterol concentrations. Animal studies have shown that animal proteins, most notably casein, increase plasma total cholesterol concentrations compared with vegetable proteins, such as soy. Soy protein has been shown to be hypocholesterolemic in rats, swine, primates, and rabbits. Epidemiologic studies have disclosed that vegetarians have lower mean plasma cholesterol concentrations than populations consuming diets of mixed proteins, but it is unclear whether this effect results specifically from the animal or vegetable nature of the protein. In human clinical experiments, substituting soy protein for mixed protein reduces plasma total cholesterol concentration in hypercholesterolemic subjects, but it causes only a small, nonsignificant change in persons with normal plasma cholesterol concentrations. The mechanism responsible for the effects of different proteins on plasma cholesterol concentrations has not been established. One hypothesis suggests that animal proteins, which have a greater content of phosphorylated amino acids than vegetable proteins, interfere with bile acid reabsorption. Another hypothesis suggests that the amino acid content of the protein affects cholesterol absorption, tissue storage, synthesis, and excretion. The dietary protein may also alter cholesterol metabolism by affecting plasma hormone concentrations, either postprandially or over weeks to months. Among the hormones thought to be affected by dietary protein source are insulin, glucagon, and thyroid hormones. Gastrointestinal hormones, such as gastrointestinal inhibitory polypeptide, may also be affected by dietary protein.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
B. L McVeigh, B. L Dillingham, J. W Lampe, and A. M Duncan
Effect of soy protein varying in isoflavone content on serum lipids in healthy young men
Am. J. Clinical Nutrition, February 1, 2006; 83(2): 244 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. M. Martins, M. Riottot, M. C. de Abreu, M. J. Lanca, A. M. Viegas-Crespo, J. A. Almeida, J. B. Freire, and O. P. Bento
Dietary Raw Peas (Pisum sativum L.) Reduce Plasma Total and LDL Cholesterol and Hepatic Esterified Cholesterol in Intact and Ileorectal Anastomosed Pigs Fed Cholesterol-Rich Diets
J. Nutr., December 1, 2004; 134(12): 3305 - 3312.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. S. Anthony, T. B. Clarkson, B. C. Bullock, and J. D. Wagner
Soy Protein Versus Soy Phytoestrogens in the Prevention of Diet-Induced Coronary Artery Atherosclerosis of Male Cynomolgus Monkeys
Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2524 - 2531.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American College of Nutrition.