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Plasma Antioxidants and Lipid Peroxidation in Acute Myocardial Infarction and Thrombolysis

Yishai Levy, MD, Peter Bartha, MD, Ami Ben-Amotz, PhD, J. Gerald Brook, MD, Gertrude Dankner, Shai Lin, MD, PhD and Haim Hammerman, MD

Lipid Research Unit (Y.L., P.B., J.G.B., G.D.), Haifa, ISRAEL
National Oceanographic Research Institute (A.B-A.), Haifa, ISRAEL
Department of Clinical Epidemiology (S.L.), Haifa, ISRAEL
Department of Cardiology (H.H.), Rambam Medical Center and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, ISRAEL



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Fig. 1. Plasma antioxidants vitamin A, E and ß-carotene in patients with AMI at baseline (0), 2 and 24 hours post STK treatment (*p<.005).

 


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Fig. 2. Plasma MDA generation at baseline and after 2 hours incubation at 37°C with 100 mM AAPH. Blood was collected from patients with AMI at 0, 2 and 24 hours after treatment by thrombolysis with STK (*p<0.05).

 


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Fig. 3. Baseline conjugated dienes (CD) generation related to STK treatment intervals. A) CD generation separated into 2 groups of patients who showed a peak CPK elevation before and 10 hours post STK treatment (*p<0.05). B) Correlation between peak CPK occurrence in hours and CD generation post STK treatment.

 





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