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Magnesium Status and Parameters of the Oxidant-Antioxidant Balance in Patients with Chronic Fatigue: Effects of Supplementation with Magnesium

Laboratory of Endocrinology, University of Antwerp (B.M.K., J.V., I.D.L.), Antwerp, BELGIUM
Department of Internal Medicine, University Hospital (G.M., M.N., I.D.L.), Antwerp, BELGIUM
Institute of Pharmacy, Free University of Brussels (J.N.), BELGIUM

View larger version (12K): [in a new window]   Fig. 1. Production of TBARS in non-HDL lipoproteins incubated with copper before (closed circles, interrupted line) and after (closed triangles, closed line) intravenous Mg given during the retention test. Values shown are mean±SEM, n=22; *p=0.01, **p=0.008 in the paired comparison before versus after the Mg infusion. Note the lack of effect of Mg on the lagphase and the significant increase of lipid peroxidation in the saturation phase.

View larger version (18K): [in a new window]   Fig. 2. Error barplots showing the effect of oral Mg supplementation in Mg deficient patients. Values shown are mean and 95% CI before (visit 1) and after (visit 2) supplementation. Closed squares and interrupted line denote patients not improving Mg stores after supplementation (non-responders, n=11), closed circles and closed line denote the responders (n=10). *p<0.05 and **p<0.005 in the paired comparison before versus after supplementation. p<0.05 and p<0.005 in the between-groups comparison responders versus non-responders.