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Conjugated Linoleic Acid and Bone Biology

Purdue University, Department of Food Science, Lipid Chemistry and Molecular Biology Laboratory, West Lafayette, Indiana, and Department of Anatomy, Indiana University School of Medicine, Indianapolis, Indiana

View larger version (32K): [in a new window]   Fig. 1. Observed effects of dietary fatty acids and related compounds on osteoblastic and osteoclastic activity in bone [44]. Excessive biosynthesis of PGE2 may depress bone formation and lead to increased bone resorption. Altering the production of eicosanoids (PGE and LTB) appears to optimize formation by osteoblasts perhaps by influencing IGF-I production and action [45].

View larger version (14K): [in a new window]   Fig. 2. Proposed mechanisms for the actions of CLA on PGE2 production (from AA) and bone metabolism. Block arrows indicate biochemical reaction processes where CLA and linoleic acid participate. Line arrows indicate possible effects of CLA and its metabolites on PGE2 metabolism and their subsequent action on bone [34]. Phospholipase A2=PLA2. Lipoxygenase enzyme=LO.