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American Ginseng Improves Glycemia in Individuals with Normal Glucose Tolerance: Effect of Dose and Time Escalation

Vladimir Vuksan, PhD,, Mark P Stavro, MSc, John L Sievenpiper, MSc, Vernon YY Koo, MSc, Evelyn Wong, MSc, Uljana Beljan-Zdravkovic, MD, MSc, Thomas Francis, PhD, Alexandra L Jenkins, BSc, RD, Lawrence A Leiter, MD,, Robert G Josse, MBBS, and Zheng Xu, MD, MSc

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre (V.V., M.P.S., J.L.S., V.Y.Y.K., E.W., U.B.-Z., T.F., A.L.J., L.A.L., R.G.J., Z.X.), St. Michael’s Hospital, Toronto, CANADA
Division of Metabolism and Endocrinology (V.V., L.A.L., R.G.J.), St. Michael’s Hospital, Toronto, CANADA



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  		Fig. 1. Effect of dose (placebo, 3g, 6g or 9g) of American ginseng (Panax quinquefolius L.) independent of time of administration on (A) incremental changes in glycemia at selected time intervals (15, 30, 45, 60 and 90 minutes) and (B) glycemic area under the curve (AUC) following a 25g oral glucose challenge in 10 nondiabetic individuals. Points at the same time interval and bars with different letters are significantly different (p<0.05; repeated measures two-way ANOVA adjusted for multiple Pairwise comparisons with the Newman-Keuls procedure). Data are mean±SEM.

 


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  		Fig. 2. Effect of time of administration (40, 80 and 120 minutes before glucose challenge) of American ginseng (Panax quinquefolius L.) independent of dose on (A) incremental changes in glycemia at selected time intervals (15, 30, 40, 60 and 90 minutes) and (B) glycemic area under the curve (AUC) following a 25g oral glucose challenge in 10 nondiabetic individuals (repeated measures two-way ANOVA adjusted for multiple Pairwise comparisons with the Newman-Keuls procedure was used for analysis). Data are mean±SEM.

 




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