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Acute Nutritional and Intestinal Changes after Pelvic Radiation

M. Pía de la Maza, MD, MSc, Martín Gotteland, PhD, Claudia Ramírez, Magdalena Araya, MD, PhD, Talía Yudin, MD, Daniel Bunout, MD and Sandra Hirsch, MD, MSc

Institute of Nutrition and Food Technology (INTA), University of Chile (M.P.M., M.G., C.R., M.A., D.B., S.H.), Santiago, CHILE
Arturo López Pérez Foundation (T.Y.), Santiago, CHILE



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  		Fig. 1. Lactulose/mannitol ratio before and after pelvic radiation. Intestinal permeability assessed by lactulose/mannitol urinary excretion, increased significantly after five weeks of pelvic radiation (p = 0.027).

 


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  		Fig. 2. Jejunal biopsies before and after pelvic radiation. A shows normal histologic appearance before radiotherapy. Biopsies after five weeks of pelvic radiation (B, C and D) show branched villae and several crypt openings to one single villus.

 




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