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Folate: A Key to Optimizing Health and Reducing Disease Risk in the Elderly

Gail C. Rampersaud, MS, RD, Gail P.A. Kauwell, PhD, RD and Lynn B. Bailey, PhD

Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida



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  		Fig. 1. Principal Components of the Folate Biochemical Cycle. Abbreviations: DHFR = dihydrofolate reductase; MTHFR = methylenetetrahydrofolate reductase. Reactions: Biosynthesis of nucleotides for incorporation into DNA and RNA; Remethylation of homocysteine to form methionine (vitamin B12 serves as a coenzyme in this reaction); Methylation of substrates, including DNA, RNA, phospholipids, and proteins; MTHFR, which catalyzes the formation of 5-methyltetrahydrofolate needed for methylation reactions; Dihydrofolate reductase enzyme.

 




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