Randomized Controlled Trial of the Effect of Bifidobacteria-Fermented Milk on Ulcerative Colitis
Hideki Ishikawa, MD,
Ikuko Akedo, MD,
Yoshinori Umesaki, PhD,
Ryuichiro Tanaka, MD,
Akemi Imaoka, MS and
Toru Otani, MD
Department of Cancer Epidemiology, Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (H.I., I.A., T.O.), JAPAN
Yakult Central Institute for Microbiological Research, Tokyo (Y.U., R.T., A.I.), JAPAN
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Fig. 1. Frequency of exacerbation in individual patients of the BFM group and control group (A) and cumulative exacerbation rates in the two groups (log rank statistical analysis, p = 0.0184) (B). At each monthly outpatient appointment, clinical symptoms were evaluated in comparison with one month earlier, as described in the Methods section. Hatched tiles show the month of the exacerbation of the symptoms of UC.
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Fig. 2. The numbers of total bacteria, total Bacterodaceae, total Bifidobacterium, and the two probiotic strains (Bif. breve strain Yakult and Bif. bifidum strain Yakult) at the commencement of the study (B) and one year later (A). *p < 0.05 (paired t test).
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Fig. 3. Ratio of each Bacteroides species in the bacteria isolated from the selective medium for Bacteroidaceae in UC patients with or without BFM supplementation. Bacteroides species were determined at the commencement of the study (B) and one year later (A). *p < 0.05 (paired t test).
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Fig. 4. Ratio of Bifidobacterium species in the bacteria isolated from the selective medium for Bifidobacterium in UC patients with or without BFM supplementation. Bifidobacterium species were determined at the commencement of the study (B) and one year later (A). *p < 0.05 (paired t test).
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Copyright © 2003 by the American College of Nutrition.
