Postprandial Leptin Response to Carbohydrate and Fat Meals in Obese Women
Monique Romon, MD, PhD,
Pascal Lebel, MSc,
Jean-Charles Fruchart, PhD and
Jean Dallongeville, MD, PhD
Service de Nutrition, Faculté de Médecine (M.R.), Institut Pasteur Lille, Lille Cedex, FRANCE
INSERM U 545 (P.L., J.-C.F.), Institut Pasteur Lille, Lille Cedex, FRANCE
INSERM U 508 (J.D.), Institut Pasteur Lille, Lille Cedex, FRANCE
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Fig. 1. Insulin, C-peptide and glucose levels before and after the carbohydrate and the fat meal in lean and obese women.
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Fig. 2. Leptin levels before and after the carbohydrate and the fat meal in lean and obese women and during the fasting experiment. Statistical analyses were carried out separately in lean and obese subjects. Two-way ANOVA with "time" (repeated factor 10 levels: 0 to 9 hours) and "meal" (repeated measures: carbohydrate/fat/fast) and their interaction was used for statistical analyses. Statistically significant (p < 0.001) interactions were found between the two factors in both lean and obese subjects.
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Fig. 3. Postprandial leptin response to the carbohydrate and the fat meal in lean and obese women. Leptin response was calculated as the difference with the corresponding fasting value of the continued fast experiment. Two-way ANOVA with weight status ("Weight status") and postprandial time (repeated measured: "Time") and their interaction ("Interaction") was used for statistical analyses. Post-hoc analyses were used to compare obese and lean subjects at each time point (* = p < 0.05).
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Fig. 4. Correlation between postprandial insulin (x-axis) and leptin (y-axis) AUC to the carbohydrate and fat meal in obese (open circles) and lean (dark triangles) women.
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Copyright © 2003 by the American College of Nutrition.
