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Efficacy of a Transforming Growth Factor ß2 Containing Nutritional Support Formula in a Murine Model of Inflammatory Bowel Disease

Department of Medicine, Section of Gastroenterology/Nutrition, Rush University Medical Center, Chicago, Illinois (H.S.O.), Louisville, Kentucky
Department of Pathology (M.R.), Louisville, Kentucky
Department of Pharmacology/Toxicology (T.S.C., C.J.M.), Louisville, Kentucky
University of Louisville Medical School, VAMC (C.J.M.), Louisville, Kentucky

View larger version (25K): [in a new window]   Fig. 1. Average Body weight (gram) for the mice on Diet-A compared to Diet-B (mean ± SEM).

View larger version (156K): [in a new window]   Fig. 2. Representative colon sections from animals on Diet-A and Diet-B stained with hematoxylin and eosin (H & E) showing mild inflammatory cell infiltration in animals on Diet-A compared to severe transmural inflammatory cell infiltrate with desquamated epithelial cells and ulcer formation in colon in animals on Diet-B.

View larger version (13K): [in a new window]   Fig. 3. Average serum concentration of cytokines, TNF-, IL-12 p70 and IFN- in Diet-A compared to Diet-B mice (mean ± SEM).