JACN
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wong, J. C.
Right arrow Articles by Chessex, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wong, J. C.
Right arrow Articles by Chessex, P.

Doubling Calcium and Phosphate Concentrations in Neonatal Parenteral Nutrition Solutions Using Monobasic Potassium Phosphate

Joyce C. Wong, BSc Pharm, Albert R. McDougal, BSc Pharm, Marianne Tofan, Dipl Pharm, Jasvinder Aulakh, BSc, Marjolan Pineault, PhD and Philippe Chessex, MD, FRCPC

Department of Pharmacy (J.C.W., A.R.M., M.T.)
Division of Neonatology (J.A., P.C.)
Children’s and Women’s Health Centre of BC, Vancouver, British Columbia, Department of Pharmacy, Hospital Ste-Justine, Montreal, Quebec (M.P.), CANADA


Figure 1
View larger version (45K):

[in a new window]
  		Fig. 1. Maximum concentration of calcium and phosphate attainable without macroscopic or microscopic evidence of precipitation in various amino acid solutions using monobasic or dibasic regimen. Trophamine and Aminosyn-PF are prepared with 40 mg HCL cysteine/g amino acid.

 

Figure 2
View larger version (53K):

[in a new window]
  		Fig. 2. Evidence of precipitation using the dibasic regimen in various amino acid solutions at increasing calcium and phosphate concentrations in a 1:1 molar ratio. Solutions were observed at three phases: immediately (t = 0 h), 24h after preparation (ppt) at room temperature (t = 24 h), and 3 hours at 37°C following 24h at room temperature (t = 27 h). Within each phase, macroscopic analysis was performed with subsequent microscopic analysis. Trophamine and Aminosyn-PF are prepared with added 40 mg HCL cysteine/g amino acid.

 

Figure 3
View larger version (52K):

[in a new window]
  		Fig. 3. Evidence of precipitation using the monobasic regimen in various amino acid solutions at increasing calcium and phosphate concentrations in a 1:1 molar ratio. Solutions were observed at three phases: immediately (t = 0 h), 24h after preparation (ppt) at room temperature (t = 24 h), and 3 hours at 37°C following 24h at room temperature (t = 27 h). Within each phase, macroscopic analysis was performed with subsequent microscopic analysis. Trophamine and Aminosyn-PF are prepared with added 40 mg HCL cysteine/g amino acid.

 

Figure 4
View larger version (20K):

[in a new window]
  		Fig. 4. Titration curves of five 3% amino acid solutions using standardized 0.1 M sodium hydroxide. Variance is not depicted when it is smaller than the size of the symbol. Trophamine and Aminosyn-PF are prepared with added 40 mg HCL cysteine/g amino acid.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American College of Nutrition.