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Korean Red Ginseng Rootlets Decrease Acute Postprandial Glycemia: Results from Sequential Preparation- and Dose-Finding Studies

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto (J.L.S., L.A.L., V.V.)
Risk Factor Modification Centre, St. Michael’s Hospital (J.L.S., M.D., L.A.L., V.V.), Toronto
Department of Biology, Faculty of Science, University of Ottawa, Ottawa (J.T.A.), CANADA
Department of Food and Nutrition, Sookmyung Women’s University, Seoul (M.S.)
Korea Ginseng Manufacturing Plant, National Agricultural Cooperative Federation, Chung-buk (K.S.L.)
Korean Ginseng and Tobacco Research Institute, Daejeon (K.Y.N.), KOREA

View larger version (28K): [in a new window]   Fig. 1. Differential effects of 3 Korean red ginseng (KRG) fractions derived from the same root source on postprandial glycemia in a preparation-finding study. The line plots and bars in the array represent the incremental change and area under the curve (AUC) for placebo (•) or one of 3 KRG-fractions—KRG-rootlets (), KRG-body (), KRG-H2O extract of whole root ()—administered at a dose of 6 g 40-min before a 50 g-OGTT in 7 healthy nondiabetic subjects (sex: 3m:4f, age: 32 ± 4 y, BMI: 24 ± 2 kg/m2). P-values reported in the base of each plot area are for the main effects of treatment and time and their interactions from repeated measures two-way ANOVA. The significant interaction between treatment and time (treatment x time) on glycemia in the case of KRG-rootlets was explored with repeated measures one-way ANOVA at each level of time. Asterisks indicate that points or bars for KRG fraction are significantly different from placebo (p 0.05, repeated measures one-way ANOVA). Data are mean ± SEM.

View larger version (28K): [in a new window]   Fig. 2. Differential effects of 3 doses of Korean red ginseng (KRG) rootlets on postprandial glycemia in a dose-finding study. The line plots and bars in the array represent the incremental change and area under the curve (AUC) for placebo (•) or one of 3 doses of KRG-rootlets—2 g (), 4 g (), 6 g ()—administered 40-min before a 50 g-OGTT in 12 healthy nondiabetic subjects (sex: 9M:3F, age: 29 ± 3 y, BMI: 22.5 ± 1 kg/m2). P-values reported in the base of each plot area are for the main effects of treatment and time and their interactions from repeated measures two-way ANOVA. Data are mean ± SEM.

View larger version (13K): [in a new window]   Fig. 3. Effect of overall Korean red ginseng (KRG) rootlets treatment (mean of 2 g, 4 g, 6 g doses) on postprandial glycemia. The line plots and bars in the represent the incremental change and area under the curve (AUC) for placebo (•) or the mean of the 3 KRG-rootlets doses () administered 40-min before a 50 g-OGTT in 12 healthy nondiabetic subjects (sex: 9M:3F, age: 29 ± 3 y, BMI: 22.5 ± 1 kg/m2). P-values reported in the base of the plot area are for the main effects of treatment and time and their interactions from repeated measures two-way ANOVA. Data are mean ± SEM.